| ncRNA name | p62/SQTSM1 siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Rattus norvegicus |
| Tissues/Cell_line | retinal Müller cell line rMC-1 |
| Methods | siRNA transfection, Western blot, immunofluorescence, immunoprecipitation, TUNEL assay, Acridine Orange staining |
| Expression pattern | associated |
| Functional description | High glucose induces increase of early and late autophagic markers, accumulation of p62/SQTSM1 and endoplasmic reticulum (ER) stress response associated with apoptosis augmentation. By silencing the p62/SQTSM1, ER stress is ameliorated (p<0.0001), preventing apoptosis. |
| PubMed ID | 27564518 |
| Year | 2016 |
| Title | Defective Autophagy in Diabetic Retinopathy. |
| Drug-related ncRNA | NO |
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